Descriptive statistics were displayed as mean ± standard deviation for continuous data and frequencies with percentages for categorical variables. Statistical analysis of the data was carried out using the Statistical Package for the Social Sciences (SPSS) version 25 (IBM, 2018). Therefore, we defined hypertensive crisis on admission as the following: (1) in chronic hypertensive patients (= antihypertensive medication was required during hospital stay and at discharge), systolic blood pressure value > 179 mm Hg and/or diastolic blood pressure value > 109 mm Hg, and (2) in normotensive patients (no antihypertensive medication was required after day of admission and at discharge), systolic blood pressure value > 159 mm Hg, and/or diastolic blood pressure value > 99 mm Hg.
It is known that previously normotensive individuals can develop signs of encephalopathy as a result of failure of the upper limit of cerebral vascular autoregulation (autoregulation breakthrough) at blood pressures as low as 160/100 mm Hg, whereas individuals with chronic hypertension may not do so until the blood pressure rises to 220/110 mm Hg or greater ( 26). In this context, hypertensive encephalopathy represents typical hypertensive sequelae of brain damage. There is a strong association with the occurrence of end-organ damage, with the brain being an elective and early target. In general, hypertensive crises are defined as an increase in systolic blood pressure >179 mm Hg or diastolic blood pressure >109 mm Hg ( 25). Chronic hypertension was assumed if antihypertensive medication was required during the hospital stay and at discharge. Chronic Hypertension/Hypertensive Crisisīlood pressure values on admission were recorded and evaluated as single blood pressure values. This means that in the group of stroke patients, the current stroke was not yet included, but a previous stroke event was considered. In addition, CHA 2DS 2-VASc scores were determined for all patients at the time of current admission. Transient global amnesia (TGA) is an acute disturbance of episodic memory for a period of 9 mm, men > 10 mm) ( 24). Our main findings show a strong association between acute hypertensive peaks and TGA in patients not adapted to chronic hypertension, indicating a vascular cause of the disease. TGA patients without DWI lesions were older and showed higher CHA 2DS 2-VASc scores compared to TGA patients with DWI lesions.Ĭonclusion: This study revealed significant differences between TGA and stroke patients in regard to the cardiovascular risk profile. Stroke patients initially displayed higher CRP levels than TIA and TGA patients. After statistical correction for age, TGA patients had higher systolic and diastolic blood pressure, higher cholesterol levels, lower HbA1c, as well as blood glucose levels, and lower CHA 2DS 2-VASc scores. Scores for cerebral microangiopathy were lower in TGA patients compared to stroke patients. A total of 90.6% of TGA patients underwent MRI, and 53% of those showed hippocampal diffusion-weighted imaging (DWI) lesions. Results: TGA patients were significantly younger and predominantly female compared to stroke patients. Methods: Cardiovascular risk profile and MR imaging of 277 TGA patients was retrospectively analyzed and compared to 216 acute ischemic stroke patients (26% TIA). This retrospective and cross-sectional study compares the cardiovascular risk profile of TGA patients with that of acute stroke patients. Several studies showed differences in vascular risk factors between TGA compared to transient ischemic attack (TIA) or healthy controls with varying results. Objective: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of <24 h. 4Department of Epileptology (Krankenhaus Mara), Bielefeld University, Medical School, Bielefeld, Germany.3Department of Neuroradiology, Evangelisches Klinikum Bethel, University Hospital OWL of the University Bielefeld, Bielefeld, Germany.2Department of Psychology, Bielefeld University, Bielefeld, Germany.1Department of Neurology, Evangelisches Klinikum Bethel, University Hospital OWL of the University Bielefeld, Bielefeld, Germany.Andreas Rogalewski 1 * Anne Beyer 1 Anja Friedrich 2 Jorge Plümer 1 Frédéric Zuhorn 1 Isabell Greeve 1 Randolf Klingebiel 3 Friedrich G.
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